Don’t let complex sequence listings delay your patents. Our expert team delivers perfectly formatted, PTO-compliant ST.26 listings – new or converted from ST.25- that pass validation first time sequence listing services. Trusted by leading patent attorneys and IP departments, we process thousands weekly, ensuring reliable, accurate support for your valuable innovations.
Sequence listings are an essential component of biotechnology patents. They serve to differentiate the invention from prior art, preclude competitors from obtaining overlapping patents, and facilitate future research and development. Mistakes in the published sequences can cause a total loss of patent protection for valuable inventions.
Our services provide the scientific and technical know – how to transform raw sequence data into patent-acceptable listings (e.g., XML according to ST.26). We guarantee that nucleotide or amino acid sequences are correctly formatted, correctly annotated, and correctly cross-referenced. Our Patent Sequence Listings Services are specially designed to support patent agents and patent attorneys at law firms or corporations.
Biotech innovators
Researchers
Patent applicants
ST.25 & ST.26 users
Institutions
Biotech innovators
Researchers
Patent applicants
ST.25 & ST.26 users
Institutions
Our budget-friendly pricing models adapt to your specific needs, offering exceptional value without compromising quality.
We provide free iterations until you're 100% satisfied with the results. Your complete confidence in our work is our ultimate goal.
We've built our reputation on providing QUICK, ECONOMIC, and ACCURATE sequence listing services. Patent law firms and corporations trust us completely for their critical IP needs, knowing we deliver flawless results every time.
No biological sequence challenge is beyond our capabilities. Our expert team confidently handles the most intricate sequence structures while ensuring 100% compliance with all patent office regulations.
Our dedicated team of 30+ biotechnology specialists prepares thousands of SEQUENCE LISTINGS DAILY. This unparalleled volume gives us unique insights into potential issues and optimal formatting strategies across diverse biological patents.
We excel at processing massive sequence listings, including projects with up to 2.5 million sequences. Our robust systems and specialized workflows ensure accuracy even at extraordinary scale.
We prioritize error-free, PTO-compliant listings above all else. In the rare case of errors, we address these cases with absolute priority at no additional cost—your success is our commitment.
Experience our effortless ordering process and expedited delivery within 4-5 business days, with even faster options available for urgent needs.
Our Patent Sequence Listing Services are designed to help patent agents and attorneys at law firms and corporations. We have become a reliable partner for our clients by providing Quick, Cost-Effective, and 100% Accurate sequence listings time and again – regardless of the biological sequences’ complexity.
Our staff is comprised of senior biotech experts who are thoroughly familiar with international sequence listing rules and the subtleties of biological information. We know the science of the sequences — and the law to safeguard them.
To ensure the process is efficient, accurate, and smooth, we use the most current tools and software that are compatible with every accepted sequence listing output format.
PTO-conforming, error-free listings are our top priority. Should errors occur, they are treated with the highest level of priority and with no additional costs since we are committed to your success.
We adheres strictly to all rules, standards, and formatting requirements of a Patent and Trademark Office (PTO). We 100% ensure each sequence listing meets fully the current rules and specifications (e.g., US (37 CFR 1.831–1.835), WIPO standard ST.26 AND US 37 C.F.R. §§ 1.821-1.825 and WIPO standard ST. 25.) mandated by patent office worldwide, including USPTO, EPO, and others.
We offer quick turnaround times and expedited delivery to have your product done in a hurry when time is critical.
We provide affordable services without compromising on quality or accuracy.
Document Analysis
We carefully review your patent documents to identify all biological sequences
Sequence Extraction
All relevant sequences are extracted and properly formatted
Listing Creation
Compliant sequence listings are generated according to required standards
Validation & Quality Check
Multi-level verification ensures complete accuracy
Delivery
Final listings provided in required formats with documentation
Individual Inventor – Genetic Tools Developer
Nigeria
Effectual Services (TheSequenceListing.com) was referred to me by a colleague, and they did not fail. They formatted my DNA sequences to the proper style and even liaised with my IP agent overseas. As a solo innovator, I greatly appreciated their transparency and assistance.
Multinational Pharma Company
USA
We had over 200 sequences to submit, and the job was overwhelming. Effectual (TheSequenceListing.com) streamlined the entire process by a systematic, error-free procedure. They collaborated seamlessly with our in-house personnel and ensured the sequence listing met all USPTO guidelines. They are currently our first choice for future filings.
University Tech Transfer Office
UK
Effectual Services (TheSequenceListing.com) provided detailed instructions on how to transform our gene data into ST.26 format. Being a university group with little hands-on experience in sequence listings, their assistance made a significant impact in our patent application being in order the first time around.
Animal Genetics Firm
Brazil
Effectual (TheSequenceListing.com) assisted us in assembling and organizing dozens of sequences across several species for a patent application worldwide. Their organism assignments and annotations were perfect. We required no revision. Great work!
We were approached by a mid-size European biotech company with an urgent desire to file an international patent application via WIPO that included a huge number of DNA and amino acid sequences. The internal team of the customer lacked software tools to generate XML-compliant sequence listings and was not familiar with the recently approved WIPO ST.26 standard.
A Japanese biotech client’s law firm approached us after their patent application was rejected due to the sequence listing not being complete in terms of ST.26 compliance. The initial document had been drafted with the legacy ST.25 standard and contained inappropriate annotations.
A sequence listing contains nucleotide and/or amino acid sequences disclosed in a patent application and forms part of the description. It includes descriptive information about each sequence, known as annotations, and conforms to the requirements of the relevant WIPO standard (ST.25 or ST.26). It allows the sequence data of an invention to be searchable within an IP office and in publicly available databases (e.g., INSDC databases).
They ensure uniformity in disclosure of biological sequences across patent applications worldwide, facilitating examination and enabling efficient electronic data exchange between patent offices.
A sequence listing is required when your patent application discloses one or more nucleotide or amino acid sequences that fall within the definition of sequence disclosure under applicable rules.
ST.26 is the current global standard for sequence listings in XML format, replacing the older ST.25 standard. It became mandatory for all international patent applications filed on or after July 1, 2022.
ST.26 differs from ST.25 by using XML instead of plain text, requiring the inclusion of D-amino acids, branched sequence portions, and nucleotide analogs. It also allows more detailed annotations with feature keys and qualifiers, and prohibits sequences shorter than 10 nucleotides or 4 amino acids, which ST.25 permits.
Yes, ST.26 is mandatory for all international patent applications (PCT) filed on or after July 1, 2022, and for many national/regional applications depending on local implementation.
All disclosed sequences with 10+ nucleotides or 4+ amino acids must be included, whether in claims, description, drawings, or sequence listing.
Yes, modified nucleotides and amino acids must be included and appropriately annotated according to ST.26 rules.
Sequences shorter than 10 nucleotides or 4 amino acids should not be included in ST.26 sequence listings unless specifically required by local rules.
WIPO’s free WIPO Sequence tool is the recommended software for preparing and validating ST.26-compliant sequence listings.
WIPO Sequence can be downloaded from the WIPO website at www.wipo.int/standards/en/sequence.
Yes, WIPO Sequence includes a validation function that checks your sequence listing for compliance with ST.26 requirements.
ST.26 sequence listings must be submitted in XML (XML = eXtensible Markup Language) format with a .xml file extension.
Size limits vary by patent office. For large files, consult your target patent office for submission options.
Yes, but late submission may require additional fees and cannot add new matter to the application.
Branched sequences should be represented as multiple linear sequences, with each branch represented separately.
D-amino acids are represented using the same one-letter codes as L-amino acids but must include a “feature” annotation specifying “D-configuration.”
Use the most restrictive symbol possible (e.g., “N” for nucleotides, “X” for amino acids) and include appropriate feature annotations.
ST.26 sequence listings must use UTF-8 encoding.
Follow your patent office requirements. For PCT applications, use the format “[application_number]_sequence_listing.xml”.
Free text in qualifier values should be in English or include both original language and English translation.
Common errors include inconsistent annotations, incorrect feature locations, missing mandatory qualifiers, and improper formatting of modified residues.
Sequence listing errors may result in requests for correction, potential filing date issues, or prosecution delays.
Correction protocols vary by jurisdiction. Generally, you must submit a replacement listing with a statement that the correction introduces no new matter.
Effectual Services is an award-winning Intellectual Property (IP) management advisory & Consulting firm.